The human body contains cannabinoid receptors; CB1 and CB2. Why? Our very own endocrine system produces what are termed “endocannabinoids”. When a receptor in the body is agonized or antagonized by a substance that works with that receptor, there is a biological response. Our endocrine system produces and releases cannabinoids to serve a purpose, to trigger a biological response. For example, endocannabinoid levels have been demonstrated to increase following painful stimuli. In animal models endocannabinoid levels have shown increase during autoimmune issues and in response to intestinal inflammation. There has also been observation of an increase in cannabinoid receptors following nerve damage. These are just a few circumstances that have sparked large amounts of research into potential human therapeutic opportunities through addition of natural cannabinoids into our daily regimen.
CB1 receptors are found predominately on neurons in the brain, spinal cord, and peripheral nervous system, but are spread throughout other areas of the body.
CB2 receptors are predominantly in immune cells; among which include leucocytes, spleen, and tonsils.
Based on the specific neuronal location, activation of the CB1 receptors in the brain produce a psychotropic effect (feeling of high, paranoia, etc). The activation of the CB2 receptors, conversely, does not cause such effects. While there are CB2 receptors in the brain, they reside on different cells that are linked to the Central Nervous System and believed to improve neuronal signaling.
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
An antagonist blocks the action of the agonist and an inverse agonist causes an action opposite to that of the agonist.
NOTE: A drug or substance can act as an agonist for a certain receptor type and an antagonist for another.
It just so happens that plants create their own cannabinoids, termed phytocannabinoids. Phytocannabinoids occur in a very large number of plants that we consume when maintaining a healthy diet.
The Cannabis plant, depending on the reference source, has between 65-100+ phytocannabinoids. The most studied and most available by percentage volume are Δ9-tetrahydrocannabinol, THC, and cannabidiol, CBD.
THC is the cannabinoid that people most associate to the cannabis plant and think of it being used to get “high”. THC is a receptor agonist to the CB1 receptors. Again, due to the neuronal location of CB1 receptors in the brain, THC triggers psychotropic activity. It also binds to other receptors and has effects outside the neurological realm.
CBD is a cannabinoid that actually acts as a receptor antagonist. When coupled with THC, it has been observed to reduce THC’s psychoactive properties. CBD has thus been found to not only have no psychotropic properties, but is believed to have anti-psychotropic properties.
There have been hundreds of research articles focusing on pharmacokinetics and pharmacodynamics of CBD, as well as clinical studies in specific disease states. The following is a list of areas where CBD is being studied and being observed to have favorable results.
**Please note that if CBD is found to help with a medical issue by way of approved clinical research; it does not mean that because a product has CBD in it, that the same results can be expected. The above clinical benefits have not been clinically studied or confirmed to be a result of adding DREEM CBD products to your daily regimen.
*The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from health care practitioners. Please consult your health care professional about potential interactions or other possible complications before using any product. The Federal Food, Drug and Cosmetic Act requires this notice. Keep out of reach of children.